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KMID : 0366220110460010036
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Korean Journal of Hematology
2011 Volume.46 No. 1 p.36 ~ p.40
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Characterization of antiphospholipid antibodies in chronic hepatitis B infection
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Huh Ji-Young
Yi Dae-Young
Hwang Seong-Gyu
Choi Jin-Jung
Kang Myung-Seo
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Abstract
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Background: Many infections are associated with antiphospholipid antibodies (aPLs). The purpose of this study was to investigate the prevalence, persistence, clinical significance, and characteristics of aPLs in hepatitis B virus (HBV)-infected patients.
Methods: This study included 143 patients with HBV infection and 32 healthy individuals as controls. The presence of anticardiolipin antibodies (aCL Ab), anti-b2-glycoprotein I antibodies (b2GPI Ab), and lupus anticoagulant (LA) was assessed.
Results: The total prevalence of aPLs in HBV-infected patients was 12.6% (18 of 143). Of these 18 patients, 15 had low to medium titers of aCL Ab (10 with IgM, 4 with IgG, and 1 with both isotypes). b2GPI Ab and LA were detected in 3 (2.1%) and 2 (1.4%) patients with HBV infection, respectively. In follow-up specimens from 14 patients with elevated levels of aCL Ab or b2GPI Ab, 10 (71.4%) showed the persistent presence of aPLs. No clinical manifestations related to aPLs were identified.
Conclusion: In HBV-infected patients, the most frequently detected antiphospholipid antibodies were IgM aCL Ab, which have a weak association with the clinical manifestations of APS. Unlike the transient presence reported for other infection-associated aPLs, most aPLs were persistently detected over a 12-week period in patients with HBV infection.
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KEYWORD
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Anticardiolipin antibodies, Anti-b2-glycoprotein I antibodies, Lupus coagulation inhibitor, Hepatitis B virus
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